Tucked away on Maryland's lower eastern shore, Pocomoke River State Park is well known for cypress swamps that border the Pocomoke River. The river originates in the Great Cypress Swamp in Delaware and flows southwesterly 45 miles to the Chesapeake Bay. The park provides a base for a vast array of outdoor and tourist activities including fishing, biking, birding, boating, hiking and more. Amenities at the park include camping, mini cabins, boat launch, picnic areas, playgrounds, picnic shelters and a swimming pool. Both portions of the park are also centrally located within 18,000 acres of the Pocomoke State Forest and its vast trail system.

There are two distinct areas of Pocomoke River State Park: Shad Landing, on the south side of the river off Route 113, and Millburn Landing, on the north side of the Pocomoke River on Route 364. It is a 25-minute drive between the two areas of Pocomoke River State Park.